发明名称 |
ANTI-ROBO4-ANTIBODY |
摘要 |
The present disclosure relates to an antibody having an anti- angiogenesis activity. More specifically, the present disclosure relates to an antibody against ROB04 and a pharmaceutical composition containing the antibody. An object of the present disclosure is to provide an anti-ROB04 antibody having an anti-angiogenesis effect, a pharmaceutical composition or the like comprising the antibody, a method for suppressing angiogenesis using the antibody, etc. Another object of the present disclosure is to provide a method for producing the antibody. Solution The antibody of the present disclosure activates the downstream signal of ROB04 and has a suppressive activity against cell migration induced by VEGF or bFGF. The antibody of the present disclosure also exhibits an anti-angiogenesis effect in in-vivo models. Thus, the problem has been solved. |
申请公布号 |
CA2868074(A1) |
申请公布日期 |
2013.10.31 |
申请号 |
CA20132868074 |
申请日期 |
2013.04.26 |
申请人 |
DAIICHI SANKYO COMPANY, LIMITED |
发明人 |
ISUMI, YOSHITAKA;SATO, TOSHIYUKI;HASEGAWA, JUN;INOUE, TATSUYA |
分类号 |
C07K16/28;A61K39/395;A61P9/10;A61P27/02;C07K16/46 |
主分类号 |
C07K16/28 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|