Oncolytic poxvirus comprising a defective i4l and/or f4l gene and composition comprising such for use in the treatment of a proliferative disease

摘要

The present invention relates to a poxvirus comprising a defective F4L and/or I4L gene, to composition comprising such poxvirus and to the methods and use of such compositions and poxviruses for therapeutic purposes, and more particularly for the treatment of cancer.