发明名称 |
LYOPHILIZED PREPARATION COMPRISING INFLUENZA VACCINE, AND METHOD FOR PREPARATION THEREOF |
摘要 |
<p>THE PRESENT INVENTION AIMS TO PROVIDE A FREEZE-DRIED PREPARATION IN WHICH THE INFLUENZA VACCINE EXHIBITS IMPROVED STABILITY. A FREEZE-DRIED PREPARATION IN WHICH THE INFLUENZA VACCINE EXHIBITS SIGNIFICANTLY IMPROVED STABILITY CAN BE OBTAINED BY FREEZE-DRYING AN AQUEOUS SOLUTION THAT MEETS THE FOLLOWING CONDITIONS (A) TO (C): (A) (I) AN INFLUENZA VACCINE, (II) A HYDROPHOBIC AMINO ACID, AND (III) ARGININE AND AN ACID ADDITION SALT THEREOF ARE INCORPORATED; (B) THE PROPORTION OF THE COMPONENT (III) IS FROM 20 TO 85% BY WEIGHT RELATIVE TO THE TOTAL AMOUNT OF THE RESULTING FREEZE-DRIED PREPARATION; AND (C) THE pH IS ADJUSTED TO BE FROM 8 TO 10 BY CONTROLLING THE PROPORTION OF ARGININE AND AN ACID ADDITION SALT THEREOF THAT FORM THE COMPONENT (III).</p> |
申请公布号 |
MY149924(A) |
申请公布日期 |
2013.10.31 |
申请号 |
MY2009PI03554 |
申请日期 |
2008.03.07 |
申请人 |
OTSUKA PHARMACEUTICAL CO., LTD. |
发明人 |
YAMASHITA, CHIKAMASA |
分类号 |
A61K39/145 |
主分类号 |
A61K39/145 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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