CHEMICAL IN SITU SULPHONATING PROCESS

摘要

THE PRESENT INVENTION RELATES TO CHEMICAL PROCESSES FOR THE MANUFACTURE OF CERTAIN QUINAZOLINE DERIVATIVES, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF. THE INVENTION ALSO RELATES TO PROCESSES FOR THE MANUFACTURE OF CERTAIN INTERMEDIATES USEFUL IN THE MANUFACTURE OF THE QUINAZOLINE DERIVATIVES AND TO PROCESSES FOR THE MANUFACTURE OF THE QUINAZOLINE DERIVATIVES UTILISING SAID INTERMEDIATES. IN PARTICULAR, THE PRESENT INVENTION RELATES TO CHEMICAL PROCESSES AND INTERMEDIATES USEFUL IN THE MANUFACTURE OF THE COMPOUND 4-(4-BROMO-2-FLUOROANILINO)-6-METHOXY-7-(1-METHYLPIPERIDIN-4-YLMETHOXY) QUINAZOLINE.