| 摘要 |
PROBLEM TO BE SOLVED: To provide controlled release of phenolic opioids.SOLUTION: A method of providing a patient with controlled release of a phenolic opioid using a prodrug capable, upon enzymatic activation, of releasing the phenolic opioid through intra-molecular cyclization leading to formation of a cyclic urea, carbamate or thiocarbamate. Specifically, this method comprises administering to the patient a corresponding compound in which a phenolic hydrogen atom has been substituted with a spacer leaving group bearing a nitrogen nucleophile that is protected with an enzymatically-cleavable moiety. |
