发明名称 |
BREAST CANCER PROGNOSIS, PREDICTION OF PROGESTERONE RECEPTOR SUBTYPE AND|PREDICTION OF RESPONSE TO ANTIPROGESTIN TREATMENT BASED ON GENE EXPRESSION |
摘要 |
The present invention provides gene expression profiles indicative of whether a patient afflicted with PR driven malignancies is likely to be responsive to treatment with a therapeutic compound that is an anti-progestin. By identifying such responsiveness, a treatment provider may determine in advance those patients who would benefit from such treatment, as well as identify alternative therapies for non- responders. Also, provided are methods of using gene expression profiles and assays for identifying the presence of a gene expression profile in a patient. Also, provided are gene expression signatures differentiating cells expressing a K388R progesterone receptor from a wild type progesterone receptor. |
申请公布号 |
WO2013162776(A1) |
申请公布日期 |
2013.10.31 |
申请号 |
WO2013US32677 |
申请日期 |
2013.03.15 |
申请人 |
LANGE, CAROL;KNUTSON, TODD;NIKAS, JASON BASIL |
发明人 |
LANGE, CAROL;KNUTSON, TODD;NIKAS, JASON BASIL |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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