发明名称 |
ADENOVIRAL VECTOR-BASED DENGUE FEVER VACCINE |
摘要 |
The invention relates to a replication-deficient adenoviral vector comprising two or more nucleic acid sequences encoding Dengue virus antigens and a chimeric hexon protein. The chimeric hexon protein comprises a first portion and a second portion. The first portion comprises at least 10 contiguous amino acid residues from a first adenovirus serotype (e.g., serotype 5 adenovirus hexon protein), optionally with one amino acid substitution. The second portion comprises (a) at least one hypervariable region (HVR) of a hexon protein of an adenovirus of a second adenovirus serotype, or (b) at least one synthetic hypervariable region (HVR) that is not present in the hexon protein of the wild-type adenovirus of the first adenovirus serotype. |
申请公布号 |
EP2654786(A1) |
申请公布日期 |
2013.10.30 |
申请号 |
EP20110804904 |
申请日期 |
2011.12.20 |
申请人 |
GENVEC, INC. |
发明人 |
BRUDER, JOSEPH, T.;MCVEY, DUNCAN;BROUGH, DOUGLAS, E. |
分类号 |
A61K39/12;A61K39/295;C07K14/075;C07K14/18;C12N15/861 |
主分类号 |
A61K39/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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