摘要 |
The present invention relates to polyene macrolide derivatives according to the formula: wherein M is a macrocyclic lactone ring; N is a polyene sugar, substituted or unsubstituted; X is independently selected from O, S, N or NH; R is independently selected from an alkyl, cycloalkyl, heterocycloalkyl aryl, heteroaryl, arylalkyl, and heteroaryalkyl group; and i is an integer from 1 to 3, with the condition that it has a negative charge or the zwitterions character is restored; or a pharmaceutically acceptable salt thereof useful as antibiotics. |
申请人 |
CENTRO DE INVESTIGACION Y DE ESTUDIOS AVANZADOS DEL INSTITUTO POLITECNICO NACIONAL (CINVESTAV);UNIVERSIDAD AUTONOMA DEL ESTADO DE MORELOS;UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO |
发明人 |
ANTILLON DIAZ, ARMANDO;CARRILLO TRIPP, MAURICIO;FERNANDEZ ZERTUCHE, MARIO;FLORES ROMERO, JOSE DAVID;JIMENEZ MONTEJO, FABIOLA ELOISA;LEON BUITIMEA, ANGEL;MORALES NAVA, ROSMARBEL;OCAMPO MARTINEZ, LILIA;ORTEGA BLAKE, IVAN;REYES ESPARZA, JORGE ALBERTO;RODRIGUEZ FRAGOSO, MARIA DE LOURDES;SANTIAGO ANGELINO, TANIA MINERVA;VARGAS GONZALEZ, MARIA CRISTINA |