| 摘要 |
PURPOSE: A novel aminopyridine derivative is provided to suppress the activity of AIMP2-DX2 which is a new target of an anticancer agent and to effectively induce apoptosis of cancer cells, thereby effectively preventing and treating cancer. CONSTITUTION: An aminopyridine derivative of chemical formula 1 or a pharmaceutically acceptable salt thereof is provided. A pharmaceutical composition for preventing or treating cancer contains the aminopyridine derivative of chemical formula 1 or a pharmaceutically acceptable salt thereof as an active ingredient. The derivative is selected among ethyl 3-[(5-chloropyridine-2-yl)amino]-2-methyl-3-oxopropanoate, ethyl 3-[(6-methylpyridine-2-yl)amino]-3-oxopropanoate, ethyl 3-oxo-3-(quinoline-3-ylamino) propanoate, ethyl 3-[(3,6-dimethylpyridine-2-yl)amino]-3-oxopropanoate, ethyl 3-[(4-hydroxypyridine-2-yl)amino]-3-oxopropanoate, ethyl 2-methyl-3-oxo-3-(quinoline-3-ylamino) propanoate, ethyl 2-methyl-3-[(6-methylpyridine-2-yl)amino]-3-oxopropanoate, and ethyl 3-[(5-chloropyridine-2-yl)amino]-3-oxopropanoate. |
