发明名称 PREPARATION OF MAYTANSINOID ANTIBODY CONJUGATES BY A ONE-STEP PROCESS.
摘要 The invention provides a one-step process for preparing a cell-binding agent cytotoxic agent conjugate comprising contacting a cell-binding agent with a cytotoxic agent to form a first mixture comprising the cell-binding agent and the cytotoxic agent and contacting the first mixture comprising the cell-binding agent and the cytotoxic agent with a bifunctional crosslinking reagent, which provides a linker, in a solution having a pH of about 4 to about 9 to provide a second mixture comprising the cell-binding agent cytotoxic agent conjugate, wherein the cell-binding agent is chemically coupled through the linker to the cytotoxic agent, free cytotoxic agent, and reaction by-products. The second mixture is then optionally subjected to purification to provide a purified cell-binding agent cytotoxic agent conjugate.
申请公布号 MX2013011215(A) 申请公布日期 2013.10.30
申请号 MX20130011215 申请日期 2012.03.29
申请人 IMMUNOGEN, INC. 发明人 XINFANG LI;JARED M. WORFUL
分类号 A61K47/48;A61P35/00 主分类号 A61K47/48
代理机构 代理人
主权项
地址