发明名称 |
PYRROLYL SUBSTITUTED DIHYDROINDOL-2-ONE DERIVATIVES, PREPARATION METHODS AND USES THEREOF |
摘要 |
Provided are pyrrolyl substituted dihydroindol-2-one derivatives represented by formula (I), pharmaceutically acceptable salts or solvates of said derivatives, or solvates of said salts, which are effective tyrosine kinase inhibitors. Also provided are the preparation methods of the above compounds, pharmaceutical compositions containing these compounds, and the use of these compounds in manufacturing drugs useful for the treatment or adjunctive treatment of tumors medicated by tyrosine kinases or proliferation or migration of tumor cells driven by tyrosine kinases in mammals (including human). |
申请公布号 |
EP2581371(A4) |
申请公布日期 |
2013.10.30 |
申请号 |
EP20110791806 |
申请日期 |
2011.03.31 |
申请人 |
QILU PHARMACEUTICAL CO., LTD |
发明人 |
WANG, JINGYI;FAN, CHUANWEN;ZHANG, LONG;XU, BOYAN;YAN, SHOUSHENG;GUO, ZONGRU;ZHANG, MINGHUI;LIN, DONG;ZHANG, ZHANTAO;ZHOU, HAOJIE |
分类号 |
C07D403/06;A61K31/404;A61K31/4439;A61K31/496;A61K31/5377;A61P35/00;C07D401/14;C07D403/14;C07D413/14 |
主分类号 |
C07D403/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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