PRYAZOLOPYRIDINE,PYRAZOLOPYRAZINE,PYRAZOLOPYRIMIDINE,PYRAZOLOTHIOPHENE AND PYRAZOLOTHIAZOLE COMPOUNDS AS MGLIRA4 ALLOSTERIC POTENTIATORS,COMPOUNDS,AND METHODS OF TREATING NEUROLOGICAL DYSFUCTION

摘要

Pyrazolopyridine, pyrazolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.