发明名称 |
Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
摘要 |
This invention relates to novel compounds of the Formula I, Ik, Iq1-21, Ir1-21, Is1-21, It1-7, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 beta-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.
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申请公布号 |
US8569292(B2) |
申请公布日期 |
2013.10.29 |
申请号 |
US20090990306 |
申请日期 |
2009.04.30 |
申请人 |
CLAREMON DAVID A.;ZHUANG LINGHANG;LEFTHERIS KATERINA;TICE COLIN M.;XU ZHENRONG;YE YUANJIE;SINGH SURESH B.;CACATIAN SALVACION;HIMMELSBACH FRANK;ECKHARDT MATTHIAS;ZHAO WEI;VITAE PHARMACEUTICALS, INC.;BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
CLAREMON DAVID A.;ZHUANG LINGHANG;LEFTHERIS KATERINA;TICE COLIN M.;XU ZHENRONG;YE YUANJIE;SINGH SURESH B.;CACATIAN SALVACION;HIMMELSBACH FRANK;ECKHARDT MATTHIAS;ZHAO WEI |
分类号 |
C07D413/10;A61K31/5355;C07D413/14 |
主分类号 |
C07D413/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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