发明名称 |
REDUCING THE IMMUNOGENICITY OF FUSION PROTEINS |
摘要 |
<p>Disclosed are compositions and methods for producing fusion proteins with reduced immunogenicity. Fusion proteins of the invention include a junction region having an amino acid change that reduces the ability of a junctional epitope to bind to MHC Class II, thereby reducing its interaction with a T-cell receptor. Methods of the invention involve analyzing, changing, or modifying one or more amino acids in the junction region of a fusion protein in order to identify a T-cell epitope and reduce its ability to interact with a T-cell receptor. Compositions and methods of the invention are useful in therapy.</p> |
申请公布号 |
CA2442363(C) |
申请公布日期 |
2013.10.29 |
申请号 |
CA20022442363 |
申请日期 |
2002.03.30 |
申请人 |
MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG |
发明人 |
GILLIES, STEPHEN D. |
分类号 |
C07K1/00;C12N15/09;A61K38/00;A61K38/22;A61K38/24;A61K38/27;A61K45/00;A61K47/00;C07K14/00;C07K14/505;C07K14/52;C07K14/54;C07K14/55;C07K14/575;C07K14/705;C07K14/725;C07K14/76;C07K16/00;C07K16/18;C07K17/00;C07K19/00;C12N15/62;G01N33/53 |
主分类号 |
C07K1/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|