Cytotoxic variants of human ribonuclease 1 (RNase 1) identified through analysis of the interaction between RNase 1 and the human ribonuclease inhibitor (hRI) as defined by the three dimensional (3-D) atomic structure of the RNase1 hRI complex are disclosed. Also disclosed is the 3-D structure of the hRI·RNase 1 complex and methods for designing the RNase 1 variants.
申请公布号
US8569457(B2)
申请公布日期
2013.10.29
申请号
US201213619192
申请日期
2012.09.14
申请人
RAINES RONALD T.;PHILLIPS, JR. GEORGE N.;JOHNSON R. JEREMY;MCCOY JASON G.;WISCONSIN ALUMNI RESEARCH FOUNDATION
发明人
RAINES RONALD T.;PHILLIPS, JR. GEORGE N.;JOHNSON R. JEREMY;MCCOY JASON G.