发明名称 |
INDUCIBLE EUKARYOTIC EXPRESSION SYSTEM |
摘要 |
Compositions and methods for the inducible expression of genes in eukaryotic cells. Expression of a nucleotide sequence of interest is controlled by a regulatory fusion protein that consists of a transcription blocking domain and a ligand-binding domain. When the cognate ligand for the ligandbinding domain is present, transcription of the nucleotide sequence of interest is blocked. Upon removal of the cognate ligand, the nucleotide sequence of interest is transcribed. The method is useful for large scale production of a desired product in eukaryotic cells.
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申请公布号 |
CA2485939(C) |
申请公布日期 |
2013.10.29 |
申请号 |
CA20032485939 |
申请日期 |
2003.05.28 |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
FANDL, JAMES P.;DOU, CHANGLIN |
分类号 |
A01K67/027;C12N15/62;C07K19/00;C12N5/10;C12N15/09;C12N15/63;C12N15/79;C12N15/85 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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