发明名称 |
STAMMER AF YARROWIA LIPOLYTICA, DER PRODUCERER STORE MÆNGDER AF ARACHIDONSYRE |
摘要 |
Engineered strains of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 10% arachidonic acid (ARA, an É-6 polyunsaturated fatty acid) in the total oil fraction are described. These strains comprise various chimeric genes expressing heterologous desaturases, elongases and acyltransferases, and optionally comprise various native desaturase and acyltransferase knockouts to enable synthesis and high accumulation of ARA. Production host cells are claimed, as are methods for producing ARA within said host cells. |
申请公布号 |
DK2458000(T3) |
申请公布日期 |
2013.10.28 |
申请号 |
DK20120152258T |
申请日期 |
2005.11.03 |
申请人 |
E. I. DU PONT DE NEMOURS AND COMPANY |
发明人 |
DAMUDE, HOWARD G.;MACOOL, DANIEL JOSEPH;PICATAGGIO, STEPHEN K.;RAGGHIANTI, JAMES JOHN;XUE, ZHIXIONG;YADAV, NARENDRA S.;ZHANG, HONGXIANG;ZHU, QUINN QUN;POLLAK, DANA M. WALTERS |
分类号 |
C12N1/16;C12N9/00;C12N9/10;C12N15/52;C12P7/64 |
主分类号 |
C12N1/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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