ADJUVANT ADDITION TO IMMUNONANOTHERAPEUTIC AGENTS

摘要

FIELD: medicine, pharmaceutics.SUBSTANCE: group of inventions refers to medicine, namely to compositions and methods for nanocarrier delivery to the immune cells capable of stimulating an immune response in T-cells and/or B-cells. The composition contains polymer nanocarriers containing an immunofunctional surface formed of a collection of binding groups, wherein the collection is bound to dendritic cells or subcapsular sinus macrophages having higher avidity and lower affinity as compared to binding antibodies, and a pharmaceutically acceptable excipient. According to some versions, the immunostimulating group represents an adjuvant. The invention also concerns a method for administering the composition for T-cell proliferation in a patient.EFFECT: group of inventions enables the nanocarriers to deliver the immunomodulating and immunostimulating agents to B-cells and/or T-cells and to enhance the immune response of the system.35 cl, 20 ex, 40 dwg