| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to pharmaceutical industry and represents a method for preparing a soft tissue filler composition, involving the stages as follows: preparing a HA (hyaluronic acid) ingredient cross-linked with at least one cross-linking agent specified in a group of 1,4-butanediol diglycidyl ether (BDDE), 1,4-bis(2.3-epoxypropoxy)butane, 1,4-bisglycidyl dioxybutane. 1,2-bis(2,3-epoxypropoxy)ethylene and 1-(2,3-epoxypropyl)-2,3 epoxycyclohexane; reducing pH of the above HA ingredient to more than approximately 7.2; and adding the solution containing lidocaine to the above HA ingredient having reduced pH as specified above to prepare the above soft tissue filler composition.EFFECT: invention provides better stability and cohesion.12 cl, 5 ex, 3 tbl, 9 dwg |
