IMIDAZOLE COMPOUNDS FOR USE AS ENZYME INHIBITORS

摘要

ABSTRACT - 593418 The disclosure relates to azole derivative compounds represented by structural formula shown herein and compositions thereof, wherein the variables are as defined in the specification. These compounds are suitable for inhibiting the enzyme fatty acid amide hydrolase (FAAH), and are useful for treating or preventing condition or disorder whose development or symptoms are linked to substrates of the FAAH enzyme, wherein the condition or disorder is selected from appetite regulation, obesity, metabolic disorders, cachexia, anorexia, pain, inflammation, neurotoxicity, neurotrauma, stroke, multiple sclerosis, spinal cord injury, Parkinson's disease, levodopa-induced dyskinesia, Huntington's disease, Gilles de la Tourette's syndrome, tardive dyskinesia, dystonia, amyotrophic lateral sclerosis, Alzheimer's disease, epilepsy, schizophrenia, anxiety, depression, insomnia, nausea, emesis, alcohol disorders, drug addictions such as opiates, nicotine, cocaine, alcohol and psychostimulants, hypertension, circulatory shock, myocardial reperfusion injury, atherosclerosis, asthma, glaucoma, retinopathy, cancer, inflammatory bowel disease, acute and chronic liver disease such as hepatitis and liver cirrhosis, arthritis and osteoporosis.