| 摘要 |
<p>Disclosed herein is the use of beta-carbolines of general formula (I), wherein the substituents are as defined within the specification, in the manufacture of a medicament for the prophylaxis and treatment of hearing damage, vertigo and vestibular disorders, particularly, acute hearing loss, acute acoustic trauma , explosion trauma, labyrinthine deafness due to chronic noise exposure, presbycusia, trauma during implantation of inner ear prosthesis (insertion trauma), vertigo due to diseases of the inner ear, vertigo in relation with and/or as a symptom of Meniere's disease, vestibular disorders in relation with and/or as symptom of Meniere's disease, tinnitus and hearing damages due to antibiotics and cytostatics. Examples of particularly preferred compounds for use include: 9-methyl-9H-?-carboline, 6-methoxy-9-iso-propyl-9H-? -carboline, 9-[(1Z)-1-methylprop-1-enyl]-9H-?-carboline, 1-chloro-9-[(1Z,3E)-2-methylpenta-1,3-dienyl]-9H-?-carboline, 9-methyl-6-propoxy-9H-?-carboline, 9-cyclopropyl-6-methoxy-9H-?-carboline, 6-trifluormethoxy-9-methyl-9H-?-carboline, 6-dimethylamino-9-methyl-9H-?-carboline.</p> |
