发明名称 |
NITROGENATED BICYCLIC AROMATIC HETEROCYCLIC COMPOUND |
摘要 |
[Problem] To provide an excellent therapeutic or prophylactic agent for autoimmune diseases, allergic diseases, graft rejection in an organ, the bone marrow or a tissue, systemic lupus erythematosus or the like, which relies on a cathepsin-S-inhibiting activity. [Solution] It is confirmed that a nitrogenated bicyclic heterocyclic compound represented by formula (I) has a good cathepsin-S-inhibiting activity, and this confirmation leads to the accomplishment of the present invention. The compound according to the present invention has a cathepsin-S-inhibiting activity and therefore can be used as a therapeutic or prophylactic agent for autoimmune diseases, allergic diseases, graft rejection in an organ, the bone marrow or a tissue, systemic lupus erythematosus or the like. |
申请公布号 |
WO2013157562(A1) |
申请公布日期 |
2013.10.24 |
申请号 |
WO2013JP61348 |
申请日期 |
2013.04.17 |
申请人 |
ASTELLAS PHARMA INC. |
发明人 |
NAKAJIMA, YUTAKA;IMADA, SUNAO;TAKASUNA, YUJI;AOYAMA, NAOHIRO;NIGAWARA, TAKAHIRO;SHIRAKAMI, SHOHEI;SHIRAI, FUMIYUKI;SATO, JUNJI;NAKANISHI, KEITA;KUBO, KAORI |
分类号 |
C07D487/04;A61K31/519;A61K31/5377;A61P37/06;A61P37/08;A61P43/00;C07D473/00 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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