发明名称 |
WNT PATHWAY INHIBITORS |
摘要 |
A class of compounds having general formula (I) has been identified. These compounds function as inhibitors of the Wnt pathway. Compounds of formula (I) are suitable for the treatment and/or prevention of any condition or disease in which it is desirable to inhibit signaling in the Wnt pathway, in particular inhibiting the proliferation of tumor cells, especially those associated with breast cancer, non-small cell lung cancer, pancreatic and colorectal cancers (e.g. colon carcinoma cells). The compounds also find use in methods of preventing metastasis and methods of promoting and/or directing cellular differentiation of progenitor cells. |
申请公布号 |
WO2013093508(A3) |
申请公布日期 |
2013.10.24 |
申请号 |
WO2012GB53248 |
申请日期 |
2012.12.21 |
申请人 |
OSLO UNIVERSITY HOSPITAL HF;GOLDING, LOUISE |
发明人 |
HOLSWORTH, DANIEL;WAALER, JO;MACHON, ONDREJ;KRAUSS, STEFAN;VORONKOV, ANDREY EDWARD |
分类号 |
A61K31/341;A61K31/351;A61K31/422;A61K31/4245;A61K31/4525;A61K31/5377;A61P35/00;C07D307/00 |
主分类号 |
A61K31/341 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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