PROGRAMMING AND REPROGRAMMING OF CELLS

摘要

Disclosed herein are novel methods and compositions for reprogramming mammalian cells. Certain methods and compositions of the invention are of use to enhance generation of induced pluripotent stem cells by reprogramming somatic cells. Certain methods and compositions of the invention are of use to identify cells destined to become iPSCs. Certain compositions and methods of the invention are of use to enhance reprogramming of pluripotent mammalian cells to a differentiated cell type. Certain compositions and methods of the invention are of use to enhance reprogramming of differentiated mammalian cells of a first cell type to differentiated mammalian cells of a second differentiated cell type. The reprogrammed somatic cells are useful for a number of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that enhances or contributes to reprogramming mammalian cells.