发明名称 |
METHOD FOR THE SELECTION OF SERUM BIOMARKERS OF EPIGENETIC ALTERATIONS, PARTICULARLY OF GLOBAL HYPOMETHYLATION AND THEIR USES |
摘要 |
The present invention provides a novel method for the selection of serum biomarkers of epigenetic alterations, particularly of global hypomethylation, and the use of said biomarkers in a method for screening, diagnosing and following a pathology associated to epigenetic alterations of cell in an individual, such as placental-related pathology or cancer. The present invention also relates to a method of detecting a predisposition to placental-related pathology or cancer based on the presence or the level of said biomarker in a serum or plasma sample of said patient. The present invention also relates to a method for predicting and following the effect of drugs targeting epigenetic modifications and in particular the effect of demethylating agents. The present invention is directed to a kit comprising such serum biomarkers of epigenetic alterations, particularly of global hypomethylation. |
申请公布号 |
WO2013156528(A1) |
申请公布日期 |
2013.10.24 |
申请号 |
WO2013EP58015 |
申请日期 |
2013.04.17 |
申请人 |
UNIVERSITE PARIS DESCARTES |
发明人 |
BELLET, DOMINIQUE;PECKING, ALAIN;RICHON, SOPHIE |
分类号 |
G01N33/574;G01N33/68 |
主分类号 |
G01N33/574 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|