发明名称 |
Cepa transformada derivada de una cepa deficiente en proteína de eflujo multifármaco y método de bioconversión utilizando la misma |
摘要 |
Disclosed is a means for improving the poor conversion efficiency in a conventional bioconversion system using a transformant which is given by introducing a gene originated from xerogenic organisms. A transformant is prepared by using a host which is defective in a gene encoding a multidrug efflux protein and introducing a gene originated from xerogenic organisms. Use of the transformant results in much effective microbial conversion of a hydrophobic or amphipathic substrate compound into a desired compound. In case, an Escherichia coli is used as the host, the gene encoding a multidrug efflux protein to be defective may be tolC, acrA, acrB and the like.
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申请公布号 |
ES2426640(T3) |
申请公布日期 |
2013.10.24 |
申请号 |
ES20080721014T |
申请日期 |
2008.02.28 |
申请人 |
MERCIAN CORPORATION;MICROBIOPHARM JAPAN CO., LTD. |
发明人 |
FUJII, TADASHI;OCHIAI, ATSUSHI;ITO, MASASHI;KABUMOTO, HIROKI;FUJII, YOSHIKAZU;MACHIDA, KAZUHIRO |
分类号 |
C12P1/04;C12P13/08;C12P17/10 |
主分类号 |
C12P1/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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