| 摘要 |
PROBLEM TO BE SOLVED: To provide a compound which is effective for treating ophthalmic disease and disorder, such as age-related macular degeneration and Stargardt's disease.SOLUTION: A compound of formula (A) or a tautomer, a stereoisomer, a geometric isomer or a pharmaceutically acceptable solvate, a hydrate, a salt, an N-oxide or a prodrug thereof is disclosed (in the formula, Z represents a bond, an -O-alkylene chain, an alkylene chain or the like, here the alkylene chain is optionally substituted by a halogen atom, a hydroxy group, or the like, G represents an alkyl group optionally substituted by a hydroxy group or the like, each of Rand Rrepresents a hydrogen atom, an alkyl group or the like, each of Rand Rrepresents a hydrogen atom, an alkyl group, an acyl group, -C(NH)NHor the like, and Rrepresents a halogen atom, an alkoxy group, an alkyl group or the like, and n represents an integer of 0 to 4). |
