| 摘要 |
PROBLEM TO BE SOLVED: To provide compounds useful as inhibitors of protein kinases.SOLUTION: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same. According to another aspect, the present invention provides a conjugate comprising any of PDGFR-α, PDGFR-&bgr;, c-KIT, cFMS, or KDR, or a mutant thereof, covalently bonded to an inhibitor at Cys814, Cys822, Cys788, Cys774, or Cys 1024, respectively. In some embodiments, the inhibitor is covalently bonded via a linker moiety. |
