NEUROMODULATORY METHOD FOR TREATING CHRONIC RHINOSINUSITIS

摘要

A closed-loop therapy delivery system for treating chronic rhinosinusitis (CRS) in a subject is provided. The therapy delivery system can comprise at least one electrode, a power source, at least one sensor, and a controller. The at least one electrode can be configured to deliver electric current to an autonomic nervous system (ANS) nerve target. The power source can be in electrical communication with the at least one electrode. The at least one sensor can be configured to detect at least one physioiogical parameter associated with CRS. The controller can be in electrical communication with the at least one electrode and the at least one sensor. The controller can be configured to automatically coordinate operation of the power source. The controller can be configured to direct delivery of the electric current to the at least one electrode to modulate activity of the ANS nerve target.