GALACTOSE CLUSTER-PHARMACOKINETIC MODULATOR TARGETING MOIETY FOR SIRNA
摘要
The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cell in vivo. The pharmacokinetic modulator improve in vivo targeting compared to the targeting ligand alone. Targeting ligand-pharmacokinetic modulator targeting moiety targeted RNAi polynucleotides can be administered in vivo alone or together with co-targeted delivery polymers.
申请公布号
EP2652134(A2)
申请公布日期
2013.10.23
申请号
EP20110848708
申请日期
2011.12.15
申请人
ARROWHEAD RESEARCH CORPORATION
发明人
HADWIGER, PHILIPP;HOFFMAN, TORSTEN;KITAS, ERIC;MOHR, PETER;ROEHL, INGO;VALIS, LINDA;ROZEMA, DAVID B.;LEWIS, DAVID L.;WAKEFIELD, DARREN, H.