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一种结合人IL‑17A的抗体，其中所述抗体包含至少1个抗体轻链可变区和至少1个抗体重链可变区，并且其中所述抗体轻链可变区具有CDR序列CDRL1、CDRL2和CDRL3，其中CDRL1由SEQ ID NO：11组成、CDRL2由SEQ ID NO：12组成和CDRL3由SEQ ID NO：13组成；和其中所述抗体重链可变区具有选自如下组的CDR序列CDRH1、CDRH2和CDRH3：(a)由序列Gly Phe Ser Leu Pro Ser His Ser Val Ser组成的CDRH1，由序列Ile Ile Trp Asn Gln Gly Gly Thr Asp Tyr Asn Ser Ala Phe Lys Ser组成的CDRH2和由序列Asn Ala Tyr Ile Thr Asp Tyr Tyr Tyr Glu Asn Tyr Phe Met Asp Ala组成的CDRH3；(b)由序列Gly Phe Ser Leu Pro Ser His Ser Val Ser组成的CDRH1，由序列Ile Ile Trp Asn Asn Gly Gly Thr Asp Tyr Asn Ser Ala Phe Lys Ser组成的CDRH2和由序列Asn Met Tyr Ile Thr Asp Tyr Tyr Tyr Glu Asn Tyr Phe Met Asp Ala组成的CDRH3；(c)由序列Gly Phe Ser Leu Pro Ser His Ser Val Ser组成的CDRH1，由序列Ile Ile Trp Asn Ala Gly Gly Thr Asp Tyr Asn Ser Ala Phe Lys Ser组成的CDRH2和由序列Asn Met Tyr Ile Thr Asp Tyr Tyr Tyr Glu Asn Tyr Phe Met Asp Ala组成的CDRH3；(d)由序列Gly Phe Ser Leu Pro Ser His Ser Val Ser组成的CDRH1，由序列Ile Ile Trp Asn Gln Gly Gly Thr Asp Tyr Asn Ser Ala Phe Lys Ser组成的CDRH2和由序列Asn Met Tyr Ile Thr Asp Tyr Tyr Tyr Glu Asn Tyr Phe Met Asp Ala组成的CDRH3；(e)由序列Gly Phe Ser Leu Pro Ser His Ser Val Ser组成的CDRH1，由序列Ile Ile Trp Asn Asn Gly Gly Thr Asp Tyr Ala Ser Ala Phe Lys Ser组成的CDRH2和由序列Asn Met Tyr Ile Thr Asp Tyr Tyr Tyr Glu Asn Tyr Phe Met Asp Ala组成的CDRH3；(f)由序列Gly Phe Ser Leu Pro Ser His Ser Val Ser组成的CDRH1，由序列Ile Ile Trp Asn Asn Gly Gly Thr Asp Tyr Gln Ser Ala Phe Lys Ser组成的CDRH2和由序列Asn Met TyrIle Thr Asp Tyr Tyr Tyr Glu Asn Tyr Phe Met Asp Ala组成的CDRH3；(g)由序列Gly Phe Ser Leu Pro Ser His Ser Val Ser组成的CDRH1，由序列Ile Ile Trp Asn Asn Gly Gly Thr Asp Tyr Asn Ser Ala Phe Lys Ser组成的CDRH2和由序列Asn Leu Tyr Ile Thr Asp Tyr Tyr Tyr Glu Asn Tyr Phe Met Asp Ala组成的CDRH3；(h)由序列Gly Phe Ser Leu Pro Ser His Ser Val Ser组成的CDRH1，由序列Ile Ile Trp Asn Asn Gly Gly Thr Asp Tyr Asn Ser Ala Phe Lys Ser组成的CDRH2和由序列Asn Ala Tyr Ile Thr Asp Tyr Tyr Tyr Glu Asn Tyr Phe Met Asp Ala组成的CDRH3；(i)由序列Gly Phe Ser Leu Pro Ser His Ser Val Ser组成的CDRH1，由序列Ile Ile Trp Asn Asn Gly Gly Thr Asp Tyr Asn Ser Ala Phe Lys Ser组成的CDRH2和由序列Asn Lys Tyr Ile Thr Asp Tyr Tyr Tyr Glu Asn Tyr Phe Met Asp Ala组成的CDRH3；(j)由序列Gly Phe Ser Leu Pro Ser His Ser Val Ser组成的CDRH1，由序列Ile Ile Trp Asn Asn Gly Gly Thr Asp Tyr Asn Ser Ala Phe Lys Ser组成的CDRH2和由序列Asn Phe Tyr Ile Thr Asp Tyr Tyr Tyr Glu Asn Tyr Phe Met Asp Ala组成的CDRH3；(k)由序列Gly Phe Ser Leu Pro Ser His Ser Val Ser组成的CDRH1，由序列Ile Ile Trp Asn Asn Gly Gly Thr Asp Tyr Asn Ser Ala Phe Lys Ser组成的CDRH2和由序列Asn Met TyrIle Thr Asp Tyr Tyr Tyr Glu Asn Tyr Phe Phe Asp Ala组成的CDRH3；(l)由序列Gly Phe Ser Leu Pro Ser His Ser Val Ser组成的CDRH1，由序列Ile Ile Trp Asn Asn Gly Gly Thr Asp Tyr Asn Ser Ala Phe Lys Ser组成的CDRH2和由序列Asn Met Tyr Ile Thr Asp Tyr Tyr Tyr Glu Asn Tyr Phe Leu Asp Ala组成的CDRH3；以及(m)由序列Gly Phe Ser Leu Pro Ser His Ser Val Ser组成的CDRH1，由序列Ile Ile Trp Asn Gln Gly Gly Thr Asp Tyr Asn Ser Ala Phe Lys Ser组成的CDRH2和由序列Asn Ala Tyr Ile Thr Asp Tyr Tyr Tyr Glu Asn Tyr Phe Phe Asp Ala组成的CDRH3。 |
