摘要 |
<p>Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.</p> |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
CHARIFSON, PAUL, S.;CLARK, MICHAEL P.;BANDARAGE, UPUL K.;DENG, HONGBO;DAVIES, IOANA;DUFFY, JOHN P.;FARMER, LUC J.;GAO, HUAI;GU, WENXIN;KENNEDY, JOSEPH, M.;LEDEBOER, MARK, W.;LEDFORD, BRIAN;MALTAIS, FRANCOIS;PEROLA, EMANUELE;WANNAMAKER, MARION W.;WANG, TIANSHENG;SALITURO, FRANCESCO, G. |