发明名称 |
NOVEL THERAPEUTIC RNA INTERFERENCE TECHNOLOGY TARGETED TO THE PDX-1 ONCOGENE IN PDX-1 EXPRESSING NEUROENDOCRINE TUMORS |
摘要 |
A bifunctional shRNA-based composition and methods for knocking down the expression of the PDX-1 oncogene in target cells is described herein. The invention also provides methods to deliver the shRNA-containing expression vectors to target tissues overexpressing the PDX-1 oncogene. |
申请公布号 |
EP2507374(A4) |
申请公布日期 |
2013.10.23 |
申请号 |
EP20100827443 |
申请日期 |
2010.10.27 |
申请人 |
GRADALIS, INC. |
发明人 |
NEMUNAITIS, JOHN, J.;RAO, DONALD;BRUNICARDI, CHARLES, F. |
分类号 |
C12N15/63;A61K31/7105;A61K48/00;A61P35/00;C12N15/113 |
主分类号 |
C12N15/63 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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