| 发明名称 |
2,4 (4,6) PYRIMIDINE DERIVATIVES |
| 摘要 |
<p>The present invention is drawn to 2,4 (4,6) pyrimidine derived macrocyclcs, pharmaceutical compositions thereof, and methods of making said compounds. The compounds disclosed herein are inhibitors of EGF receptor tyrosine kinases and are useful for treating cell proliferative disorders, including atherosclerosis, restenosis, and cancer.</p> |
| 申请公布号 |
EP1824856(B1) |
申请公布日期 |
2013.10.23 |
| 申请号 |
EP20050819148 |
申请日期 |
2005.12.08 |
| 申请人 |
JANSSEN PHARMACEUTICA NV |
发明人 |
FREYNE, EDDY JEAN E.;WILLEMS, MARC;EMBRECHTS, WERNER C. J.;VAN EMELEN, KRISTOF;VAN BRANDT, SVEN F. A.;ROMBOUTS, FREDERIK J R |
| 分类号 |
C07D487/08;A61K31/505;A61P35/00;C07D209/00;C07D221/00;C07D239/00;C07D241/00;C07D259/00;C07D273/00;C07D487/22;C07D498/18 |
主分类号 |
C07D487/08 |
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