发明名称 |
AMINO ACID-CONJUGATED CYANOACRYLATE POLYMER PARTICLES |
摘要 |
<p>Disclosed are cyanoacrylate polymer particles which comprise an amino acid(s) and have an average particle diameter of less than 1000 nm. The amino acid-containing particles according to the present invention can kill cancer cells by inducing apoptosis-like cell death. The particles have an especially high affinity for cell lines derived from lymphomas such as T-cell lymphoma and B-cell lymphoma. The particles can also exhibit an antiproliferative effect against some kinds of pancreatic cancer-derived cell lines. Therefore, the particles according to the present invention are useful for prevention and/or treatment of cancers.</p> |
申请公布号 |
EP2404598(A4) |
申请公布日期 |
2013.10.23 |
申请号 |
EP20100748772 |
申请日期 |
2010.03.03 |
申请人 |
PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY |
发明人 |
SHIROTAKE, SHOICHI;YOSHIDA, ATSUSHI;YOKOTA, SHUMPEI;ENDO, ITARU |
分类号 |
A61K31/198;A61K9/14;A61K9/51;A61K31/401;A61K31/405;A61K31/4172;A61K31/785;A61K47/32;A61K47/34;A61K47/36;A61K47/48;A61P35/00 |
主分类号 |
A61K31/198 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|