发明名称 |
Antibodies specific for sclerostin and methods for increasing bone mineralization |
摘要 |
Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.
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申请公布号 |
US8563271(B2) |
申请公布日期 |
2013.10.22 |
申请号 |
US201213592116 |
申请日期 |
2012.08.22 |
申请人 |
WINKLER DAVID G.;SHI JIYE;LATHAM JOHN;UCB MANUFACTURING, INC. |
发明人 |
WINKLER DAVID G.;SHI JIYE;LATHAM JOHN |
分类号 |
C12N15/00;A61P19/10;C07K14/51;C07K16/18;C12N15/09;C12N15/13;C12N15/63 |
主分类号 |
C12N15/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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