TERNARY NON-LAMELLAR LIPID COMPOSITIONS OF STRUCTURE FORMING AMPHIPHILE, STRUCTURE SWELLING AMPHIPHILE AND DISPERSION STABILISING AMPHIPHILE

摘要

The present invention provides a particulate composition including; a) at least 50 % of at least one structure forming amphiphile, b) 0 to 40 % of at least one structure swelling amphiphile, and c) 2 to 20 % of at least one dispersion stabilising polymeric amphiphile, where all parts are by weight relative to the sum of the weights of a+b+c and wherein the composition comprises non-lamellar particles or forms non-lamellar particles when contacted with an aqueous fluid. Where component b) is 0 % then component a) comprises at least two structure forming amphiphiles. The invention also provides pharmaceutical compositions of the compositions and kits containing the compositions for establishing a pharmaceutical formulation of an active agent.