| 发明名称 |
MACROCYCLIC COMPOUNDS AS ANTIVIRAL AGENTS |
| 摘要 |
A class of macrocyclic compounds offormula (I), wherein R1, R3, R4, R a, R b, A, Z, Y, X, M, W,n and m are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Also provided are processes 5 for the synthesis and use ofsuch macrocyclic compounds for treating or preventing HCV infection. Formula (I): |
| 申请公布号 |
CA2699891(C) |
申请公布日期 |
2013.10.22 |
| 申请号 |
CA20082699891 |
申请日期 |
2008.07.17 |
| 申请人 |
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A.;MERCK & CO., INC. |
发明人 |
LIVERTON, NIGEL;SUMMA, VINCENZO;MCCAULEY, JOHN;HARPER, STEVEN;BUTCHER, JOHN;DI FILIPPO, MARCELLO;DI FRANCESCO, MARIA EMILIA;FERRARA, MARCO;ROMANO, JOSEPH J.;RUDD, MICHAEL |
| 分类号 |
C07K5/08;A61K31/00;A61K38/00;C07K5/12 |
主分类号 |
C07K5/08 |
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