发明名称 Adenine derivatives
摘要 The present invention relates to compounds of formula (I): wherein R1 is C1-6alkylamino, or C1-6alkoxy; R2 is a group having the structure: n is an integer having a value of 1 to 6; Het is a 6-membered saturated heterocycle containing one nitrogen atom wherein Het is attached to the -(CH2)n- moiety at any carbon atom of the heterocycle; R3 is hydrogen, C1-8alkyl, or C3-7cycloalkylC0-6alkyl; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.
申请公布号 US8563717(B2) 申请公布日期 2013.10.22
申请号 US200913058465 申请日期 2009.08.07
申请人 BAZIN-LEE HELENE;COE DIANE MARY;LAZARIDES LINOS;MITCHELL CHARLOTTE JANE;SMITH STEPHEN ALLAN;TRIVEDI NAIMISHA;GLAXOSMITHKLINE LLC 发明人 BAZIN-LEE HELENE;COE DIANE MARY;LAZARIDES LINOS;MITCHELL CHARLOTTE JANE;SMITH STEPHEN ALLAN;TRIVEDI NAIMISHA
分类号 A61K31/522;A61P29/02;A61P37/08;C07D473/16 主分类号 A61K31/522
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