Anvendelse af antagonistiske anti-CD40-monoklonale antistoffer
摘要
Methods of therapy for treating diseases mediated by stimulation of CD40 signaling on CD40-expressing cells are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40-expressing cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of human CD40-expressing cells, such as B cells.
申请公布号
DK2149585(T3)
申请公布日期
2013.10.21
申请号
DK20090075395T
申请日期
2004.11.04
申请人
NOVARTIS VACCINES AND DIAGNOSTICS, INC.
发明人
LONG, LI;LUQMAN, MOHAMMED;YABANNAVAR, ASHA;ZAROR, ISABEL;CHEN, BAO-LU;LU, XIAOFENG;LEE, SANG HOON;HURST, DEBORAH