POLYPEPTIDE WITH RECRUITING ACTIVITY OF STEM CELL

摘要

PURPOSE: A polypeptide with stem cell recruiting activity is provided to enable effective angiogenesis and tissue regeneration, thereby being used as a therapeutic agent for treating vasoocclusion-related diseases, especially ischemic diseases. CONSTITUTION: A polypeptide with stem cell recruiting activity contains self-assembly peptides with an amino acid sequence of general formula 1 ((alpha beta)_n) and substance P which are conjugated. Substance P has an amino acid sequence of sequence number 2. A spacer with 2-10 repetitive sequences including glycine (G) or glutamic acid (E) is conjugated at N-terminal of the amino acid sequence of sequence number 2.