COMPOSITION FOR PHOTOTHERMAL THERAPY HAVING PHOTOACTIVE MULTIMERIC FULLERENES, METHOD FOR PREPARING THE SAME, AND PHOTOTHERMAL THERAPY USING THE SAME

摘要

PURPOSE: A composition containing photoactive multimeric fullerenes for photothermal therapy is provided to prevent cytotoxicity because the composition is easily discharged to the outside of the body and decomposed by cleavable ester bond. CONSTITUTION: A composition for photothermal therapy contains monomeric fullerenes which are conjugated by cleavable ester bond and contains photoactive multimeric fullerenes with photoactive molecules and targeted materials. A photothermal therapy for animals exclusive of human comprises the steps of: administering the composition to a test subject; and percutaneously irradiating the test subject by light at 500-800 nm. A method for preparing the photoactive multimeric fullerenes comprises the steps of: preparing biocompatible polymers containing ester groups and having a functional group at both ends; introducing a reactive group to one end of the photoactive molecule and the targeted material for functionalization; making the biocompatible polymers react with monomeric fullerenes in a solvent; and adding a reactant of the introduction step to prepare photoactive multimeric fullerenes.