| 发明名称 |
METHOD OF CONTROLLING CONDITIONS FOR SITE-SPECIFIC BINDING OF POLYPEPTIDE AND NON-PEPTIDE POLYMER |
| 摘要 |
FIELD: chemistry.SUBSTANCE: present invention provides a method of controlling conditions for site-specific binding of a polypeptide and a non-peptide polymer by controlling pH and alcohol content of the reaction medium.EFFECT: method is intended to prevent formation of secondary conjugates, wherein a non-peptide polymer binds with a physiologically vital amino acid residue.15 cl, 36 dwg, 25 ex |
| 申请公布号 |
RU2495881(C2) |
申请公布日期 |
2013.10.20 |
| 申请号 |
RU20110142332 |
申请日期 |
2010.03.18 |
| 申请人 |
KHANMI KHOLDINGS KO., LTD. |
发明人 |
SONG DAE KHAE;SHIN DZAE KHI;LI DZAE MIN;PARK JANG KIUNG;KVON SE CHANG;LI GVAN SUN |
| 分类号 |
C07K14/575;A61K47/48;C07K1/18;C07K14/605;C07K14/62 |
主分类号 |
C07K14/575 |
| 代理机构 |
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