发明名称 |
NUCLEOTIDE ANALOG COMPOSITION AND SYNTHESIS METHOD |
摘要 |
PROBLEM TO BE SOLVED: To provide an antiviral compound.SOLUTION: The invention provides a composition comprising bis(POC)PMPA and fumaric acid (1:1). The composition is useful as an intermediate for the preparation of antiviral compounds, or is useful for administration to patients for antiviral therapy or prophylaxis. The composition is particularly useful when administered orally. The invention also provides methods to make PMPA and intermediates in PMPA synthesis. Embodiments include lithium t-butoxide, 9-(2-hydroxypropyl) adenine and diethyl p-toluenesulfonylmethoxy-phosphonate in an organic solvent such as DMF. The reaction results in diethyl PMPA preparations containing an improved by-product profile compared to diethyl PMPA made by prior methods. |
申请公布号 |
JP2013213071(A) |
申请公布日期 |
2013.10.17 |
申请号 |
JP20130151752 |
申请日期 |
2013.07.22 |
申请人 |
GILEAD SCIENCES INC |
发明人 |
MUNGER JOHN D JR;ROHLOFF JOHN C;SCHULTZE LISA M |
分类号 |
A61K31/662;A61K31/675;A61K9/20;A61K47/12;A61K47/26;A61K47/36;A61K47/38;A61P31/12;C07D473/34;C07F9/6561 |
主分类号 |
A61K31/662 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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