| 摘要 |
PROBLEM TO BE SOLVED: To provide compositions and methods for preparation of poorly water-soluble drugs with increased stability.SOLUTION: The invention provides stable pharmaceutical compositions of poorly water-soluble pharmaceutical agents and stabilizing agents which function to increase stability of the compositions. The use of stabilizing agents provides extended stability of nanoparticle suspensions and other formulations of poorly water-soluble pharmaceutical agents such as docetaxel under certain conditions, for example upon dilution for administration. Accordingly, in one aspect, the invention provides compositions (such as pharmaceutical compositions) comprising a poorly water-soluble pharmaceutical agent (such as docetaxel) and a stabilizing agent, wherein stability of the composition is enhanced as compared to that of a composition without the stabilizing agent. |
