发明名称 |
Stable Solid Formulation of GC-C Receptor Agonist Polypeptide Suitable for Oral Administration |
摘要 |
Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr ("linaclotide"; SEQ ID NO:1) or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.
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申请公布号 |
US2013273169(A1) |
申请公布日期 |
2013.10.17 |
申请号 |
US201313837631 |
申请日期 |
2013.03.15 |
申请人 |
FOREST LABORATORIES HOLDINGS LIMITED;IRONWOOD PHARMACEUTICALS, INC. |
发明人 |
FRETZEN ANGELIKA;WITOWSKI STEVEN;GROSSI ALFREDO;ZHAO HONG;DEDHIYA MAHENDRA;MO YUN |
分类号 |
A61K38/10;A61J3/00;A61K9/16 |
主分类号 |
A61K38/10 |
代理机构 |
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