发明名称 |
AMINOHYDROXYLATION OF ALKENES |
摘要 |
The invention relates to a process for the aminohydroxylation of alkenes using N-oxycarbamate reagents, e.g. N-acyloxycarbamate, N-alkyloxycarbonyloxycarbamate and N-aralkoxycarbonyloxycarbamate reagents. The invention particularly relates to an intermolecular aminohydroxylation reaction that can be carried out in the absence of added base. The invention also relates to novel N-oxycarbamate reagents that are stable crystalline materials. The process of the invention is useful in the synthesis of compounds having a vicinal amino alcohol moiety, such as biologically active compounds.
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申请公布号 |
US2013274479(A1) |
申请公布日期 |
2013.10.17 |
申请号 |
US201113704896 |
申请日期 |
2011.06.20 |
申请人 |
MEE SIMON PETER HAROLD;LUXENBURGER ANDREAS;HARRIS LAWRENCE DANIEL;INDUSTRIAL RESEARCH LIMITED |
发明人 |
MEE SIMON PETER HAROLD;LUXENBURGER ANDREAS;HARRIS LAWRENCE DANIEL |
分类号 |
C07C269/06;C07D207/14;C07D207/273;C07D307/33;C07D498/04;C07F9/40 |
主分类号 |
C07C269/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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