发明名称 |
ADSORPTION OF IMMUNOPOTENTIATORS TO INSOLUBLE METAL SALTS |
摘要 |
Immunopotentiators can be adsorbed to insoluble metal salts, such as aluminium salts, to modify their pharmacokinetics, pharmacodynamics, intramuscular retention time, and/or immunostimulatory effect. Immunopotentiators are modified to introduce a moiety, such as a phosphonate group, which can mediate adsorption. These modified compounds can retain or improve their in vivo immunological activity even when delivered in an adsorbed form.
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申请公布号 |
US2013274465(A1) |
申请公布日期 |
2013.10.17 |
申请号 |
US201113820370 |
申请日期 |
2011.09.01 |
申请人 |
SINGH MANMOHAN;SKIBINSKI DAVID A.G.;WU TOM YAO-HSIANG;LI YONGKAI;CORTEZ ALEX;ZHANG XIAOYUE;ZOU YEFEN;HOFFMAN TIMOTHY Z.;PAN JIANFENG;YUE KATHY;IRM LLC;NOVARTIS AG |
发明人 |
SINGH MANMOHAN;SKIBINSKI DAVID A.G.;WU TOM YAO-HSIANG;LI YONGKAI;CORTEZ ALEX;ZHANG XIAOYUE;ZOU YEFEN;HOFFMAN TIMOTHY Z.;PAN JIANFENG;YUE KATHY |
分类号 |
C07F9/6561;C07F9/645;C07F9/6512;C07F9/6558 |
主分类号 |
C07F9/6561 |
代理机构 |
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