Spectral imaging for measurement of nuclear pathology features in cancer cells prepared for in situ analysis
摘要
In general, the presently disclosed technology relates to identification of cancer subtypes. More specifically, the technology relates to methods for determining molecular drivers of cancer and/or progression using a multivariate image data and statistical analysis of in-situ molecular markers and morphological characteristics in the same cells of a biological sample suspected of cancer. This analysis takes place after a single acquisition that obtains the molecular and anatomic morphology data in parallel. The analysis compares specific morphological and molecular markers to known samples exhibiting particular genetic drivers of the cancer. This method provides statistical information that allows for an increased confidence in the identification of specific molecular drivers of the cancer.
申请公布号
AU2012252532(A1)
申请公布日期
2013.10.17
申请号
AU20120252532
申请日期
2012.05.07
申请人
CORNELL UNIVERSITY;VENTANA MEDICAL SYSTEMS, INC.
发明人
DEMICHELIS, FRANCESCA;GARSHA, KARL;MILLER, PHILLIP C;NAGLE, RAY B;OTTER, MICHAEL;PESTANO, GARY ANTHONY;RUBIN, MARK A.