发明名称 CONJUGATE OF FOLATE AND ANTIBODY, PREPARATION METHOD AND USE THEREOF
摘要 Anti-tumor conjugates, which consists of folic acid or analogues thereof, linkers, an antibodies such as immunoglobulin G. The linker comprises glutathione, cysteamine or cysteine residue, and further comprises N-hydroxysuccinimide. The Conjugates target folate-receptor-positive tumor cells. Also provided are preparation methods and anti-tumor and anti-autoimmune disease uses of the conjugates.
申请公布号 EP2650309(A1) 申请公布日期 2013.10.16
申请号 EP20110839201 申请日期 2011.05.14
申请人 WUHAN HUAYAO BIOPHARMACEUTICAL CO., LTD 发明人 LIU, YING
分类号 C07K16/30;A61K39/395;A61K47/42;A61K47/48;A61P35/00;A61P37/02 主分类号 C07K16/30
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